The European Medicines Agency said on Tuesday, that with regard to the Johnson & Johnson Covid-19 Vaccine Janssen – it has found a “possible link to very rare cases of unusual blood clots with low blood platelets.”

However, it also confirmed the “overall benefit-risk remains positive.” EMA’s safety committee (PRAC) concluded that a warning about unusual blood clots with low blood platelets should be added to the product information for Covid-19 Vaccine Janssen.

PRAC also concluded that these events should be listed as “very rare side effects” of the vaccine.

In reaching its conclusion, the Committee said that it took into consideration all currently available evidence including eight reports from the United States of serious cases of unusual blood clots associated with low levels of blood platelets, one of which had a fatal outcome.

As of the 13th of April, over 7 million people had received Janssen’s vaccine in the United States.

It was also explained that all cases occurred in people under 60 years of age within three weeks after vaccination, the majority in women. Based on the currently available evidence, “specific risk factors have not been confirmed.”

PRAC noted that the blood clots occurred mostly at unusual sites such as in veins in the brain (cerebral venous sinus thrombosis, CVST) and the abdomen (splanchnic vein thrombosis) and in arteries, together with low levels of blood platelets and sometimes bleeding.

The cases reviewed were very similar to the cases that occurred with the Covid-19 vaccine developed by AstraZeneca, Vaxzevria, it said.

PRAC said that healthcare professionals and people who will receive the vaccine should be aware of the possibility of very rare cases of blood clots combined with low levels of blood platelets occurring within three weeks of vaccination.

Covid-19 is associated with a risk of hospitalisation and death, PRAC said. “The reported combination of blood clots and low blood platelets is very rare, and the overall benefits of Covid-19 Vaccine Janssen in preventing Covid-19 outweigh the risks of side effects.”

EMA’s scientific assessment underpins the safe and effective use of Covid-19 vaccines. Use of the vaccine during vaccination campaigns at national level will take into account the pandemic situation and vaccine availability in individual Member States.

It was also explained that “one plausible explanation for the combination of blood clots and low blood platelets is an immune response, leading to a condition similar to one seen sometimes in patients treated with heparin called heparin induced thrombocytopenia, HIT.”

PRAC emphasised the importance of prompt specialist medical treatment. By recognising the signs of bloods clots and low blood platelets and treating them early, healthcare professionals can help those affected in their recovery and avoid complications.

It stressed that, “thrombosis in combination with thrombocytopenia requires specialised clinical management. Healthcare professionals should consult applicable guidance and/or consult specialists (e.g., haematologists, specialists in coagulation) to diagnose and treat this condition.”

As for all vaccines, EMA said that it will continue to monitor the vaccine’s safety and effectiveness and provide the public with the latest information.

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